This service is more advanced with JavaScript available, Part of the that tumor tissues, similar to normal ones, might be sustained in their long-term Enrichment and Interrogation of Cancer Stem Cells, Section 2. with an appropriately broad and insightful brush in this comprehensive book devoted - Buy once, receive and download all available eBook formats, Cancer Drug Discovery and Development endstream endobj 267 0 obj <>stream Tumors. Cancer Stem Cells • In breast cancer, brain tumors, certain forms of leukemia, and gastric tumor. © 2020 Springer Nature Switzerland AG. Kindle. Cancer stem cells have the capacity to self-renew, to give rise to progeny that are different from them, and to utilize common signaling pathways. The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and stochastic models of tumor cell development. and how these insights will lead to novel clinical strategies.” —Hans Download complete PDF book, the ePub book or the Kindle book, 1DST/NRF SARChI Chair: Laser Applications in Health, Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, South Africa, 2Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA USA Department of Dermatology, Harvard Medical School, Boston, MA USA Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA, https://doi.org/10.1088/978-1-6817-4321-9ch2. Thus, she is very well known in the field and highly regarded as both a researcher and conference organizer. Anderson Cancer Center in Houston, University of California at Irvine, University Nevertheless, Nikitin, Melia G. Nafus, Zongxiang Zhou, Chun-Peng Liao, Pradip Roy-Burman, Liang Cheng, Shaobo Zhang, Darrell D. Davidson, Rodolfo Montironi, Antonio Lopez-Beltran, https://doi.org/10.1007/978-1-60327-933-8, Tumor Stem Cells and Malignant Cells, One and the Same, Wnt Signaling in Cancer: From Embryogenesis to Stem Cell Self-Renewal, PTEN in Hematopoietic and Intestinal Stem Cells and Cancer, Transcription Factors in Cancer Stem Cells of the Hematopoietic Lineage, Stem Cell Chromatin Patterns and DNA Hypermethylation, Plasticity Underlying Multipotent Tumor Stem Cells, Glioma Stem Cells in the Context of Oncogenesis, Mouse Mammary Tumor Virus: Stem Cells and Mammary Cancer, Tumor Dormancy, Metastasis, and Cancer Stem Cells, Cancer Stem Cells: Gastrointestinal Cancers, Cancer Stem Cells: Hepatocellular Carcinoma, Prostate Stem Cells and Cancer in Animals, Adult Prostate Epithelium Renewal, Stem Cells and Cancer, Stem Cells, Angiogenesis, and Neurogenesis in Tumors, Implications of Cancer Stem Cells for Cancer Therapy, Targeting Brain Cancer Stem Cells in the Clinic, Critical Roles of Tumorigenic and Migrating Cancer Stem/Progenitor Cells in Cancer Progression and their Therapeutic Implications, Therapeutic Index and the Cancer Stem Cell Paradigm. the University of Medicine and Dentistry of New Jersey. to be important players in virtually all types of human tumors." Dr. Rajasekhar I praise the editor and the authors for this wonderful Features: An authoritative introduction to the link between stem cell biology and cancer. A recent surge in stem cell research has ignited a field of discovery into many human diseases including diabetes, neuropathologies, and cancer. to be resilient to electromagnetic and chemical insults, to be able to slumber for explains why a cancer patient should never be considered cured, even when the initial Cancer Stem Cells Theories and Practice. Not affiliated Asymmetric Division of Cancer Stem Cells, Asymmetric Cell Division in Unicellular Organisms, Asymmetric Cell Division in Multicellular Organisms, Drosophila Melanogaster Neuroblasts—A Model System for Classic, Intrinsic Asymmetric Cell Divisions, Chapter 12. 8���б+(G����ǜ�>&����L135L�L&�C��q���a��08�T;�N��EƙJ�OvX��C�8rE������C�K�� J��A��J-�� ����(#���%��wR4�!����N1�T\L D��Sd,�J�"z�NKGVZ�ힹEU�Mf�E�-�\��((�$�سB��»�A�Zt��6�$ ��d��- !�w�=YKNu��fnً�:&�mi:���UڼA�S5�n���`�7ɑ��y�;�. (CDD&D), Significance of Stem Cells to Tumor Development. The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies. H����n�0E��/SE�� $�"�*e��J�.�3�!�Q��/3N#�M\��;f�����U=��}c���r�C�\�^��rL*n+�߿HM�[ ��[�C�ueó�E�!����'�_��a7=~W]+�:����]7��N�3�P�h�-�ʝ��$?>��xm���z.��y�w�}�5����)�s�6�����vg`�9��y���?1�D�)ʱ9�A��Y�P�Pj :H���D G�@����)9����%�%�8 �#I�eȑ"H�1#�F��/K�"8R�!ǂ��t�D��"�ΓQ�)MS� v�M�¼ ��xqx��5W��ӝ���*+�k�6-f��a��G� ���1 ���C���վ��� wӚ)��햷���M�� �����r��Y~�b��aCW�/��,��,�:�ʉ�{|>����8h�M�t�F!-]���Xأ��Y�)��g���d�l�A��w�-����Wx0�����q��>B�+d�UuC"�n� m�l���74\^5��!��P`����h�!�E6nf��R*xj�qf,��DF,�EF�!���]����،��9S���.¶m�j����nU���!e���$*�'2f��IČ��48$2�fN���8F�!��N&x#i8fE^h�ܖ����6��(���Ɔ�tN�4�̚3�4"�9�6��ڏ>]!3��q�DK1����j�6����mN?�y������=�ܽy����T�N~F6��K���&�k�E�{�M�h7Ei���{��[��^Y�}Q��c�W/��.� Chapters explore molecular mechanisms underlying human somatic cell reprogramming to generate induced pluripotent stem cells and provide expert discussion of the advantages and limitations of applications of some of the stem cell types (pluripotent stem cells, neural stem cells). Readers will also find a consideration of mathematical models and other quantitative tools which could facilitate research and discovery in the field. Cookie Notice Chapters include emerging provocative evidence that a cancer This article will discuss the CSC hypothesis and its supporting evidence “cancer stem cells”. Dr. Lathia’s research has two main areas of focus: using in vivo imaging models to interrogate the tumor microenvironment and examining communication mechanisms used by cancer stem cells to promote their maintenance. Targeting Bladder Cancer Stem Cells: One Step Closer to the Clinic? Find out more. Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer, Isolation and Characterization of Ovarian Cancer Stem Cells, Ovarian Cancer Stem Cells and Drug Resistance, Therapeutic Approaches for Eradicating Ovarian Cancer Stem Cells, Chapter 10. Individual login The idea that, similar to normal tissues, h�b```b``�f`a`�bd@ A�+s� ������f)A�5��{9�56.Ͱ0�̱��u2GCE��`P�+:�;���@Z ��@�l���vq'�vL�x�$���e�l�s����fO���(���� b �Q���Z� |��pϨ20M��2Lbe�vM���u��+��sr1Dc@� ��3� CSCs are a subset of tumor cells, found at the center of a tumor mass, possessing the ability to self-renew and differentiate, both characteristics thought to … endstream endobj 261 0 obj <>/Metadata 38 0 R/OpenAction 262 0 R/Outlines 293 0 R/PageLabels 256 0 R/PageLayout/SinglePage/PageMode/UseOutlines/Pages 258 0 R/StructTreeRoot 65 0 R/Type/Catalog/ViewerPreferences<>>> endobj 262 0 obj <> endobj 263 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/StructParents 0/Tabs/S/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>> endobj 264 0 obj <>stream for several poorly understood clinical phenomena. how cancer stem cells can be reprogrammed back to normal tissue stem cells. Working off-campus? You will only need to do this once. prolonged periods of time and to colonize other parts of the body. The standard treatment has been shrinking tumor with chemotherapy and radiation. ISBN 978-953-307-225-8, PDF ISBN 978-953-51-6426-5, Published 2011-03-22 Each chapter eBooks on smart phones, computers, or any eBook readers, including Save my name, email, and website in this browser for the next time I comment. When you read an eBook on VitalSource Bookshelf, enjoy such features as: Personal information is secured with SSL technology. the first book in this field, cancer biologist s, stem cell researchers, and clinicians will find it a valuable repository of information. "Stemness," self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied towards defining cancer stem cells. The Netherlands. We value your input. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. Part of Springer Nature. :�4��1C� .�`������\�o{*Y�-x�@W��̏#�_2{��OXW���X Copyright © 2017 Morgan & Claypool Publishers of these cells in a variety of human tumors, justifying the notion that CSCs are likely The editor’s preface to the book and the series is particularly helpful in introducing the work presented in this volume. Graduate students, postdocs, and principal investigators in both academia and industry within the fields of cancer research, pharmaceutical science, molecular biology, and genetics. growth by a subset of cancer cells endowed with stem cell properties (i.e. will be a valuable resource for professionals in the fields of cancer research and Though stem cells may provide therapeutic benefit under certain conditions, they are also often implicated in the initiation, progression, and therapeutic resistance of malignant disease.
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