This site needs JavaScript to work properly. Kunst Linear regression models were fit by variance-weighted least-squares (since the method does not assume homoscedasticity). We found that smear-negative index cases accounted for 25% of all secondary latent infections and 18% of new active cases and therefore represent a significant transmission risk. All rights reserved. A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA). The reduction in the viable count was reflected by a corresponding increase in the time to positivity of the mycobacterial growth indicator tube (MGIT) liquid culture: 1.2 days at 23°C (P < 0.001) and 1.1 days at 30°C (P < 0.001). Diaz Our study had a number of limitations. Hai HT, Vinh DN, Thu DDA, Hanh NT, Phu NH, Srinivasan V, Thwaites GE, T T Thuong N. Tuberculosis (Edinb). | BF A consultant radiologist (A. IW Zellweger Index cases that were not culture positive in sputum were therefore censored at 70 days (although they may have been culture positive from another respiratory sample such as bronchoalveolar lavage fluid). Kik Evaluation of sputum decontamination methods for Mycobacterium tuberculosis using viable colony counts and flow cytometry. Transmission was strongly associated with age (P < .001); index cases aged 20–39 years had the highest risk of transmission (OR, 2.91; AOR, 2.18; Table 2). Solari R NALC-NaOH decontamination of sputum reduces the viable M. tuberculosis count measured by MBLA. ML A culture test involves studying bacteria by growing the bacteria on different substances. When the analysis was restricted to smear-negative patients, the direction of the association was consistent with the results presented above (for a TTD < 9 days, univariable OR, 3.93). It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Torrella This work did not require any funding support. Ethical approval was obtained from the West of Scotland Research Ethics Committee for retrospective review of case notes and radiography. Our study confirms the contribution of NALC-NaOH treatment to the loss of viable bacterial counts. S The converse was used for the relative transmission rate of smear-negative patients [32, 33]. et al. Hernandez-Garduno Of the 184 cases of pulmonary tuberculosis reported during the study period, 111 were included in the final study, and these generated 825 contacts. L TTD has been shown to be inversely correlated with bacterial burden and is therefore a surrogate measure of bacillary load [11]. TTD data within strata of CXR grade are presented as box plots with Tukey whiskers (the dots represent outliers). It has been suggested that such quantification may be used to guide duration of isolation of patients with pulmonary tuberculosis and also as a predictor of treatment response [16, 17, 35, 36]. For Permissions, please e-mail: Thank you for submitting a comment on this article. It may be expected that smear-positivity is not predictive in the multivariable model as smear-positivity and TTD are both surrogate measures of bacillary burden in sputum. Enarson R Although liquid culture systems were not developed to quantitatively measure bacillary numbers, TTD has been shown to correlate well with mycobacterial burden [10, 11]. et al. Stavropoulos Stead
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