Submitted hESC Lines Pending Review: The following is a list of human embryonic stem cell lines submitted to NIH, which are PENDING review to determine if they may be used in NIH funded research. [3][4], Researchers are currently focusing heavily on the therapeutic potential of embryonic stem cells, with clinical use being the goal for many laboratories. Formerly approved hESC lines will be phased out: Since July 2009, the National Institutes of Health (NIH) has begun to re-evaluate and re-approve human embryonic stem cell (hESC) lines for federal funding. [9], ESCs divide very frequently due to a shortened G1 phase in their cell cycle. It is expected that many new hESC lines will be approved and added to the new registry. Embryonic stem cells (ES cells or ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. OPCs and their mature derivatives called oligodendrocytes provide critical functional support for nerve cells in the spinal cord and brain. [20], Besides becoming an important alternative to organ transplants, ESCs are also being used in field of toxicology and as cellular screens to uncover new chemical entities (NCEs) that can be developed as small molecule drugs. Pending Lines: Sorted by: Date/Time: 15 (in 4 Submissions) Cell Line Name [46] Evans and Kaufman showed that the cells grown out from these cultures could form teratomas and embryoid bodies, and differentiate in vitro, all of which indicating that the cells are pluripotent. [40] The makers of the stem cell therapy, Geron Corporation, estimated that it would take several months for the stem cells to replicate and for the GRNOPC1 therapy to be evaluated for success or failure. The CIRM permits hESC lines on the new NIH Stem Cell Registry to be used in CIRM-funded research (see CIRM statement), as well as hESC lines certified on their own list of Acceptably Derived Embryonic Stem Cells. It is important to respect donors’ wishes, whether they donate embryos no longer needed for assisted reproduction or donate gametes that are used to create embryos. [66] He was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent." The mission of the hESC Core at the Yale Stem Cell Center (YSCC) is to provide essential services for research on human embryonic stem cells (hESCs) to researchers in the State of Connecticut and to serve as a central location for Connecticut investigators conducting studies of non-federally-approved hESC lines. [1][2] Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells. In addition, this will allow the generation of ES cell lines from patients with a variety of genetic diseases and will provide invaluable models to study those diseases.
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