Clipboard, Search History, and several other advanced features are temporarily unavailable. 2017 Jun;10(6):551-561. doi: 10.1080/17474086.2017.1326814. Copyright © 2014 Elsevier Ltd. All rights reserved. USA.gov. Please enable it to take advantage of the complete set of features! Finally, in the third review, Pawlyn and Davies address the question of personalized treatment based on molecular characteristics of the disease. Lancman G, Tremblay D, Barley K, Barlogie B, Cho HJ, Jagannath S, Madduri D, Moshier E, Parekh S, Chari A. Clin Adv Hematol Oncol. It is unfortunate that the key question in this process, “Why does a quiescent clone become aggressive in some patients while it remains stable in others?” is yet to be answered. Genadieva Stavric S, Bonello F, Bringhen S, Boccadoro M, Larocca A. Get the latest public health information from CDC: https://www.coronavirus.gov. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Autologous stem-cell transplantation and agents such as thalidomide, lenalidomide, and bortezomib have changed the management of myeloma and extended overall survival. Advances in therapy have resulted in a marked improvement in overall survival. 2019 Oct 18;5(4):e159-e162. 2019 Oct 9;2019:2079439. doi: 10.1155/2019/2079439. Copyright © 2020 Elsevier B.V. or its licensors or contributors. All rights reserved. Both Methylation and Copy Number Variation Participated in the Varied Expression of PRAME in Multiple Myeloma. 2020 Apr;30(4):1927-1937. doi: 10.1007/s00330-019-06469-1. Skeletal abnormalities in multiple myeloma. eCollection 2019 Oct. Muñoz-Bermúdez R, Abella E, Zuccarino F, Masclans JR, Nolla-Salas J. Multiple myeloma is a cancer of the blood cells. 2015 Jun;38(3):315-21. doi: 10.1097/COC.0b013e3182a4676b. AJNR Am J Neuroradiol. Treatment options for multiple myeloma have grown a great deal in the past few years. Inhibition of Multiple Myeloma Using 5-Aza-2'-Deoxycytidine and Bortezomib-Loaded Self-Assembling Nanoparticles. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. The second player in MM pathogenesis consists of the interaction between the malignant clone and stromal cells through direct contact, soluble molecules, or exosomes, thus promoting tumor progression and drug resistance. NLM Medications, natural treatments, and other things that can help. For this reason, imaging plays a significant role in the management of MM patients. Find key information about multiple myeloma, including the cancer causes, symptoms, tests, and treatment today. Cytogenetic testing for specific mutations can identify patients at particularly high risk of morbidity and mortality. It accounts for 10%–15% of all hematologic malignancies, and 20% of deaths related to cancers of the blood and bone marrow. AJR Am J Roentgenol. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. 2020 Jun 5;11:1128. doi: 10.3389/fimmu.2020.01128. Myeloma today: Disease definitions and treatment advances. The main point of this discussion is whether we should just look to OS as a treatment goal, or if the first progression-free survival (PFS) is important. It is our hope that this review series will contribute to the stimulation of translational research and lead to a better understanding of new criteria for the diagnosis, monitoring, and treatment of MM. SK has obtained research support for clinical trials from Celgene, Millennium, Novartis, Janssen, Sanofi. Clipboard, Search History, and several other advanced features are temporarily unavailable. In this review, we outline the current approach to the diagnosis, prognosis, and management of multiple myeloma. Although exact causes remain unknown, scientists have made progress in understanding how certain abnormalities and mutations in DNA cause plasma cells to become cancerous: However, will this still be the case with the frontline use of monoclonal antibodies? Progress in MM treatment and patients’ survival has reinforced the need for better tools to prognosticate and monitor treatment efficacy. The articles in this review series, “Multiple myeloma: from the bench to bedside,” include the following: “Pathogenesis beyond the cancer clone(s) in multiple myeloma” by Giada Bianchi and Nikhil C. Munshi, “New criteria for response assessment: role of minimal residual disease in multiple myeloma” by Bruno Paiva, Jacques J. M. van Dongen, and Alberto Orfao, “Smoldering multiple myeloma” by Vincent Rajkumar, Ola Landgren, and María-Victoria Mateos, “Frontline therapy of multiple myeloma” by Philippe Moreau, Michel Attal, and Thierry Facon, “Treatment options for relapsed and refractory multiple myeloma” by Ajay K. Nooka, Efstathios Kastritis, Meletios A. Dimopoulos, and Sagar Lonial. Please enable it to take advantage of the complete set of features! https://doi.org/10.1016/j.mporth.2014.05.007. This site needs JavaScript to work properly. USA.gov. It is responsible for osteoclast activation and osteoblast downregulation, with resultant bone destruction and painful fractures. 2005 Jan;234(1):312-3; author reply 313. doi: 10.1148/radiol.2341040991. Many new options are currently available for the treatment armamentarium of MM, including recently approved drugs (such as the second- and third-generation proteasome inhibitors carfilzomib and ixazomib and the immunomodulatory agent pomalidomide), as well as other emerging agents with novel mechanisms of action (eg, monoclonal antibodies, histone deacetylase inhibitors, and kinesin spindle protein inhibitors) that are under active investigation. Stäbler A, Baur A, Bartl R, Munker R, Lamerz R, Reiser MF. Authorship Contributions and Disclosure of Conflicts of Interest SVR declares no conflict of interest. Biology has moved from morphology and low-sensitivity protein analysis into genomics, while therapeutics has moved from only 1 active agent (melphalan) to almost uncountable potentially active drug combinations. Myeloma is a cancer of the plasma cells in the bone marrow. Published by Elsevier Inc. All rights reserved.  |  2016;57(10):2084-2095. doi: 10.11406/rinketsu.57.2084. Kohsari M, Khadem-Ansari MH, Rasmi Y, Sayyadi H. Asian Pac J Cancer Prev. HHS Role of MRI for the diagnosis and prognosis of multiple myeloma. In the second review, Kumar et al discuss the role of frontline high-dose melphalan (HDM) in the management of transplant-eligible patients. In Europe, HDM is the standard of care for all MM cooperative groups, whereas in the United States, it is becoming either a salvage treatment option or not considered in the treatment pathway for MM patients.

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