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Circulation 121, 1992–2000 (2010). Media releases, information for representatives of the media, © 2020 An international research group led by Prof. Nadia Mercader of the University of Bern now shows that certain heart muscle cells play a central role in this process. Article  (2020), Journal of Cardiothoracic and Vascular Anesthesia Hassink, R. J. et al. Herget, G. W., Neuburger, M., Plagwitz, R. & Adler, C. P. DNA content, ploidy level and number of nuclei in the human heart after myocardial infarction. Chimenti, I. et al. Such a cure could save thousands of lives, improve the quality lives of millions of heart failure patients and save the health care economy billions of dollars every year. While cures may be good for patients, they may not be a good medical business model. Zwi, L. et al. 2, 107–111 (2010). Annu. Nature Med. 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The group of Nadia Mercader from the Institute of Anatomy at the University of Bern has been interested in understanding the cellular mechanisms of heart regeneration during the last 10 years. PLoS ONE 5, e11134 (2010). Am. Internet Explorer). Oregon Health & Science University is dedicated to improving the health and quality of life for all Oregonians through excellence, innovation and leadership in health care, education and research. Segers, V. F. & Lee, R. T. Stem-cell therapy for cardiac disease. Yu, J. et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nature 428, 664–668 (2004). Natl Acad. Proc. Engel, F. B., Hsieh, P. C., Lee, R. T. & Keating, M. T. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Until recently, it was thought that humans were born with all of the heart cells they would ever have throughout life. If this is the case, the researchers believe that this finding could be of great importance in stimulating the repair process in the human heart. Circ. USA 103, 15546–15551 (2006). Google Scholar. A phase I study of intermittent intravenous bromodeoxyuridine (BUdR) with conventional fractionated irradiation. Rumyantsev, P. P., Erokhina, I. L., Antipanova, E. M. & Martynova, M. G. DNA and sex chromatin content in nuclei of conductive system and working myocytes of normal and hypertrophied human heart. Am. Development. PubMed  Google Scholar. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Call your clinic or see MyChart for details. ADS  Thomson, J. Role of the ATP-binding cassette transporter Abcg2 in the phenotype and function of cardiac side population cells. Circ. Cell Reports, Vol. 12, 452–458 (2006). Cell number in human heart in atrophy, hypertrophy, and under the influence of cytostatics. ADS  Sci. Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach. CAS  68, 1560–1568 (1991). Thank you for visiting nature.com. Poss, K. D., Wilson, L. G. & Keating, M. T. Heart regeneration in zebrafish. Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Google Scholar. PubMed  At the heart of regeneration: Scientists reveal a new frontier in cardiac research Date: November 12, 2019 Source: Children's Hospital Los Angeles Moretti, A. et al. Natl Acad. Prevascularization of cardiac patch on the omentum improves its therapeutic outcome. "We were able to identify a specific cell population that is more efficient than all other heart muscle cells during regeneration, and showed that its contribution to repair is essential," says Mercader.

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