Watch the Cancer.Net Video Managing Side Effects of Chemotherapy, with Jyoti D. Patel, MD, adapted from this content.. present a case report on fatal toxicity induced by a combination of dichloroacetate and artemisinin derivative, artesunate. Articles, Pôle de Pharmacologie et de Thérapeutique, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Belgium. Thus, inactivation of the cannabinoid system might be useful to counteract CIC, whilst cannabinoid receptor activation might be used to counteract CID (Abalo et al., 2017; McQuade et al.). Kerckhove et al. (2017). Biology of premature ageing in survivors of cancer. Received: 09 February 2018; Accepted: 05 March 2018; Published: 22 March 2018. doi: 10.5430/jst.v6n2p43, Zhou, Y. Q., Liu, D. Q., Chen, S. P., Sun, J., Zhou, X. R., Rittner, H., et al. Chemotherapy can prolong a person’s life, and potentially rid them of cancer. Improved cancer survival and newer forms of chemotherapy have increased exposure to neurotoxic agents. provide a comprehensive review of pathophysiological mechanisms, symptoms and risk factors of long-term CIPN induced by specific types of chemotherapeutic drugs. Redox Biol. Editorial on the Research Topic Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? These synergistic effects of nutraceutical compounds such as flavonoids, stilbenes, terpenes, curcumin, and others have been discussed in a review article by Redondo-Blanco et al. medical officer at Jindal Steel & Power Ltd. Clipping is a handy way to collect important slides you want to go back to later. Management of adverse effects of cancer chemotherapy 1 1. New approaches to improve tolerance and reduce sequelae of cancer chemotherapy are urgently needed and the present Research Topic focuses on this issue and highlights several areas of progress. describe the pathophysiology, and current and emerging treatments for chemotherapy-induced constipation (CIC) and diarrhea (CID), both of which are common and may require dose reductions, delays or even cessation of treatment. presented in this Research Topic. report encouraging results for a potential protective effect of a botanical, Emblica officinalis (Indian gooseberry). doi: 10.1136/esmoopen-2017-000250, Younus, J., Kligman, L., and Jawaid, D. (2016). Kumar et al. Younger children, girls and those with other allergies are at higher risk and the incidence rises with increased number of infusions rather than simply drug dosage. Adverse effects can range from mild changes such as dry eyes, to severe changes such as retinal damage and glaucoma.8, Cardiovascular effects can be among the most serious adverse events resulting from chemotherapy, and can occur early or late during the treatment. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Another platinum-based chemotherapeutic, cisplatin, may increase the risk of cardiovascular disease in cancer survivors. Journal of Solid Tumors. Thus, further studies of neuroprotective agents to combat this type of neurotoxicity may also be warranted. Appetite loss. Some patients have been known to refuse chemotherapy because of the risk of alopecia.2, Chemoradiotherapy-induced hypogonadism and angiopathy cause libido loss in both men and women,3 and certain therapies given to adolescent and young adult patients with cancer can lead to infertility in the future.3, Chemotherapy-induced cutaneous toxicity affects about 60% to 80% of the population receiving chemotherapy. Over-use of anti-diarrhoeal treatments for CID is one frequent cause of CIC, but other mechanisms of CIC are not well understood. See Fertility and Cancer. Finally, we hope that by identifying and minimizing or preventing both short and longer-term toxicity from cancer chemotherapy, the treatments themselves will be better tolerated and more effective, and the health and wellness of cancer survivors will be enhanced. The effects are sometimes dose-related. Food intake may be compromised due to mouth sores.5, Cancer treatment can cause low platelet count, or thrombocytopenia (platelet count ≤30,000). Herradón et al. ESMO Open 2:e000250. GI effects can occur during or after administration of chemotherapy and can vary in severity (eg, soft stool to bloody diarrhea).9, Chemotherapy treatment can affect a patient’s memory or attention span. Learn more about these and other problems in Managing Cancer-related Side Effects. Eur. Adverse effects can range from mild changes such as dry eyes, ... “Chemo-brain” can be a side effect of cancer therapy that causes memory loss and other cognitive changes. (2017). Mosińska et al. Our mission is to provide practice-focused clinical and drug information that is reflective of current and emerging principles of care that will help to inform oncology decisions. Examples include skin rash, dryness, pruritus, paronychia, hair abnormalities, and mucositis.4, Mucositis is a common side effect experienced as a result of radiation therapy and chemotherapy treatment; severity varies from patient to patient. describe the pathobiology and treatment of cancer treatment-related mucosal injury. You can change your ad preferences anytime. is included in this Research Topic. Sign in Cancer treatments can cause many other side effects, including tiredness, trouble eating, and … 29:e12952. Sundar et al. For other women, chemotherapy may cause periods to stop completely (menopause). Fatigue can result from a number of factors, including anemia, depression, and radiation therapy.1 Similarly, alopecia affects many patients and can be one of the most disturbing side effects, sometimes preventing people from receiving chemotherapy.2, Sexual dysfunction resulting from chemotherapy and radiation therapy can often result in loss of libido.3 Affecting about 60% to 80% of patients receiving chemotherapy, cutaneous toxicities can include skin rash4 and mucositis. MANAGEMENT OF ADVERSE EFFECTS OF CANCER CHEMOTHERAPY 2. The impact of cold therapy on the incidence and severity of paclitaxel induced peripheral neuropathy: A pilot study. Studies show that such hypersensitivity reactions occur in up to 47% of children treated with this agent. McQuade et al. Effects of chemotherapy on women. |, Creative Commons Attribution License (CC BY). provide a detailed and timely review of current knowledge about these immune-related adverse events and a framework for clinical management. A Unique Easy To Follow 5-Step Plan To Eliminating Vitiligo And Related Auto-Immune Skin Disorders Using Proven Holistic Strategies. Clinicians should be aware of the adverse events that can result from administration of certain agents. here. If you continue browsing the site, you agree to the use of cookies on this website. CID is potentially fatal due to dehydration and electrolyte imbalance and current therapeutic approaches include re-hydration, loperamide, and octreotide. We look forward to more new studies to answer these and many other related questions and we anticipate that this will continue to be a dynamic and expanding area of research. This likely reflects the complexity of the pathobiology of gastrointestinal mucositis, and highlights the fact that mucosal injury probably contributes to other chemotherapy-induced gastrointestinal disorders. Mucositis is also one of the common side effects experienced as a result of radiation therapy and chemotherapy treatment, with mouth sores often affecting food intake.5, Thromobocytopenia (low platelet count) can affect clotting and cause bleeding, and is caused by alkylating, antirheumatic, and antimetabolite agents.6,7 Damage to the optic nerve and the ocular motor nerves can often occur when a patient is receiving antineoplastic chemotherapy. See our Privacy Policy and User Agreement for details. Chemotherapy treats many types of cancer effectively. Chemotherapy can cause fatigue in patients. Kim et al. Certain chemotherapy drugs are toxins, which can build up in the body faster than the liver can process them, and ultimately, can result in liver damage.11, Antineoplastic chemotherapy can cause damage to the optic nerve and the ocular motor nerves. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Too busy to workout? Interestingly, using radiographic methods in rats, Vera et al. These are usually given to prevent you … CLASSIFICATION OF ANTICANCER DRUGS CELL CYCLE SPECIFIC AGENTS 5. doi: 10.1111/nmo.12952, PubMed Abstract | CrossRef Full Text | Google Scholar, Andrews, P. L., and Sanger, G. J. Long-term CIPN is associated with high morbidity including depression, ataxia, insomnia. Without enough red blood cells to carry oxygen to tissues, you may experience anemia.Symptoms of anemia may include: 1. fatigue 2. lightheadedness 3. pale skin 4. difficulty thinking 5. feeling cold 6. general weaknessChemo can also lower your white blood cell count (neut… One of the drawbacks of rodent models in the development of antiemetic drugs is that rodents lack the emetic reflex. In their review, Cinausero et al. Copyright © 2020 Haymarket Media, Inc. All Rights Reserved Central and peripheral neurotoxicity caused by anti-cancer drugs can last many years after the end of treatment and can dramatically reduce functional capacity and quality of life in cancer survivors. (2018). The results of this study suggest that continuous-flow limb hypothermia can preserve specific parameters of nerve conduction and significantly benefit some patients undergoing paclitaxel chemotherapy. One example, namely the occurrence of hypersensitivity reactions to carboplatin in children being treated for solid tumors such as low-grade glioma, is reviewed by Ruggiero et al. Routine blood count monitoring is a crucial part of chemotherapy. explored the possible mechanisms for this, using 5 weekly intraperitoneal injections of cisplatin, in male Wistar rats.

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