It is no exaggeration to say that to be well acquainted with MHC is a shortcut to control rejection. Thus, specific shared eplets should always be investigated with respect to previous transplant mismatches. Get the latest research from NIH: https://www.nih.gov/coronavirus. Gebel HM, Bray RA, Nickerson – Pre-transplant assessment of donor-reactive, HLA-specific antibodies in renal transplantation. The human leukocyte antigen system or complex is a group of related proteins that are encoded by the major histocompatibility complex gene complex in humans. A better understanding of the immunogenicity and structural characteristics of HLA epitopes will guide us to consider epitope matching as an important parameter for donor selection in kidney transplant in the near future. Novel aspects of epitope matching and practical application in kidney transplantation. For this, B cells are able to recognize polymorphic amino acid configurations, which are named epitopes. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. may email you for journal alerts and information, but is committed | Curr Opin Organ Transplant. | Current status and future perspectives of HLA-edited induced pluripotent stem cells. 800-638-3030 (within USA), 301-223-2300 (international). For immediate assistance, contact Customer Service: Slide 6: The main role of the HLA lab is to assess and monitor the immunological risk of a donor-recipient pair. New approaches for crossing the HLA barrier in transplantation using plasmapheresis, intravenous immunoglobulin and kidney paired donation have been made possible by the relative ease with which even low levels of anti-HLA antibodies can now be detected and tracked. 2012 Jul-Aug;44(6):1648-51. doi: 10.1016/j.transproceed.2012.04.006. The influence of HLA matching on solid organ and bone marrow transplantation is also described. Argani H(1). Clipboard, Search History, and several other advanced features are temporarily unavailable. 3. Log in to view full text. The development of novel protocols for the induction of tolerance and new approaches to immunomodulation was also facilitated by advances in HLA technology. access full text with Ovid®. 2. Some error has occurred while processing your request. Epub 2014 Apr 25. Transpl Immunol. Genetic Engineering of the Kidney to Permanently Silence MHC Transcripts During. Transplanting Sensitized Kidney Transplant Patients With Equivalent Outcomes Utilizing Stringent HLA Crossmatching. The item(s) has been successfully added to ", This article has been saved into your User Account, in the Favorites area, under the new folder. Dragun, Duska; Philippe, Aurélie; Catar, Rusan, Clinic for Nephrology and Intensive Care Medicine, Campus Virchow-Klinikum and Center for Cardiovascular Research, Medical Faculty of the Charité Berlin, Berlin, Germany, Correspondence to Professor Dr Duska Dragun, Department of Nephrology and Intensive Care Medicine, Charité Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany. Get the latest research from NIH: https://www.nih.gov/coronavirus. Please try again soon. The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. Lippincott Journals Subscribers, use your username or email along with your password to log in. Advancements in tissue typing have introduced HLA matching at the epitope level. Current Opinion in Organ Transplantation: Current Opinion in Organ Transplantation17(4):440-445, August 2012. 800-638-3030 (within USA), 301-223-2300 (international) eCollection 2019. to maintaining your privacy and will not share your personal information without Corsello T, Amico G, Corrao S, Anzalone R, Timoneri F, Lo Iacono M, Russo E, Spatola GF, Uzzo ML, Giuffrè M, Caprnda M, Kubatka P, Kruzliak P, Conaldi PG, La Rocca G. Stem Cell Rev Rep. 2019 Dec;15(6):900-918. doi: 10.1007/s12015-019-09907-1. [email protected]. Please enable it to take advantage of the complete set of features! Exp Clin Transplant. However, we should not forget that the inn… Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. You may be trying to access this site from a secured browser on the server. Get new journal Tables of Contents sent right to your email inbox, August 2012 - Volume 17 - Issue 4 - p 440-445, Role of non-HLA antibodies in organ transplantation, Articles in Google Scholar by Duska Dragun, Other articles in this journal by Duska Dragun. In the context of transplantation, HLA molecules are polymorphic antigens that comprise an immunodominant alloreactive … Am J Kidney Dis. Wharton's Jelly Mesenchymal Stromal Cells from Human Umbilical Cord: a Close-up on Immunomodulatory Molecules Featured In Situ and In Vitro. 2018 May;71(5):720-731. doi: 10.1053/j.ajkd.2017.09.021. Curr Opin Organ Transplant. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. 2010 Jun;8(2):130-5. 2014 Jun;31(1):1-6. doi: 10.1016/j.trim.2014.04.004. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. This program (HLAMatchmaker) uses structurally defined eplets to describe epitopes that can react with specific antibodies. Recent developments have been achieved for better matching in solid-organ transplantation by epitope matching. Wolters Kluwer Health Curr Opin Organ Transplant. HLA Epitope Matching in Kidney Transplantation: An Overview for the General Nephrologist. Keywords Kidney transplant in highly sensitized patients after desensitization with plasmapheresis and low-dose intravenous immunoglobulin. | 2011 Jul-Aug;43(6):2411-4. doi: 10.1016/j.transproceed.2011.05.039. Epitopes are present on a single HLA (private epitope) or shared by multiple antigens (public epitope). Exp Clin Transplant. Data is temporarily unavailable. NCI CPTC Antibody Characterization Program. In the context of transplantation, HLA molecules are polymorphic antigens that comprise an immunodominant alloreactive trigger for the immune response, resulting in rejection. Sensitive antibody tests with a comprehensive panel of single alleles have yielded informative, donor-specific antibody reactivity patterns that can be analyzed with a computer algorithm.
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