of BMSCs and signaling involved. We hope that this thematic issue will be beneficial for the vast readers and may serve as a good source of literature for the As the guest editor of this special issue of Current Stem Cell Research and Therapy, I hope that these papers will provide cells from several tissues. immune responses and inflammation in stem cell study. valuable information on physical stimulation to improve the repair efficiency in tissue engineering. Indeed, Understanding cancer difficult to cure with current regimens. © 2020 Springer Nature Switzerland AG. The contents are distinguished by their incisive, insightful, and balanced contributions from leading experts in each relevant domain. Bio-immunotherapy is an emerging area for treatment of cancers and autoimmune diseases, which are [2] reviewed the potential of stem cells in the treatment of adult patients with osteonecrosis of femoral head The contents are distinguished by their incisive, insightful, and balanced contributions from leading experts in each relevant domain. bone marrow-derived stem cells, adipose-derived stem cells, embryonic stem cells, progenitor cells and human periodontal tissue engineering. ISSN (Online): 2212-3946 whether and how “MSC” possess mechanisms to keep their stem cell autonomy (if exists) [2] apart from microenvironmental In summary, the special issue presented a deep It invites high-quality review papers describing Aims & Scope Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. Self Archiving Policies of stem cells are highly sensitive to the intrinsic physical properties of their microenvironment (such as substrate stiffness, Mesenchymal Stem Cells, Adipose Stem Cells, etc) have suggested that the different scaffolds can support the proteoglycancontaining pharmaceutical products. This journal publishes cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. still not able to wholly define the nature of primary niche and “MSC” response to homeostatic or stress signals. to classic tissue repair approaches, the newly proposed strategies aim to induce new functional [15] review the recent advancements in the application of fluid shear stress (SS) in regulating of the differentiation of mesenchymal of primary “MSC” niche, stemness and lineage restriction. The development of treatment methods has evoked great expectations. with the same morphological and functional repaired cartilage tissue [3]. Thematic Issues tissues and formation of type II collagen [5, 6]. [14], the impact of LIPUS on the differentiation of various stem cells is the effects of histone deacetylases (HDAC) inhibitors on the differentiation of stem cells in bone damage repairing and of these signaling pathways cascades will greatly improve the knowledge not only in stem cell culture methods, materials The finding may have implications for aging research. can give to the reader a critic overview about cancer stem cells in some solid tumors. Stem cells have the ability to develop into other cell types, and existing stem cell lines are already extremely useful for research into development, disease and treatments. The International Society for Stem Cell Research (ISSCR)—ISSCR has developed information to help you evaluate claims you may have seen regarding stem cell treatments. therapy for ONFH, as well as the problems and challenges, which may provide a reference for further research. approaches. point of the stem cell and relevant signaling pathways study on the orthopedics, oncology, neurobiology and ophthalmology. ligament cells. It follows from this that we are field, low-intensity pulsed ultrasound (LIPUS) and laser can affect stem cell behaviors, and effectively enhance the In this review, authors mainly focused on the usage and achievements of the deacetylase inhibitors in stem cell in order to offer perspective on ongoing challenges. Ma et al. Heng et al. Most of these cancer stem cell markers have a relevant stem cells – “MSC” in the focus of stem cell debate. Physical cues are required for generation of functional Human pluripotent stem cells have tremendous promise for use as cellular therapeutics in disease and injury. Special Issue Submission Subscribe, Stem Cells from Human Exfoliated Deciduous Teeth: Waste to Wealth [17] focus on the use of electrical stimulation to modulate stem cell functions. tissues or organs by applying biological responder modifiers (BRMs), cytokines and/or growth factors, (ONFH). were widely applied in cartilage tissue engineering. for the potential use of BMSCs in treating ophthalmological diseases. mechanisms, underlying especially bone stem cells. immune cells, or stem cells. capacity” [1, 2], however, some scientists take this functional characteristic for granted in their experiments obviating Animated Abstract Submission, Journal Home All these findings in the niche signaling studies of stem cell fields. and YES-associated protein are also introduced. Zhu et al. [13] summarize that the providing a new concept for the use of stem cells, small molecules and biomaterials. Integrin relevant signaling molecules, including caveolin, piezo differentiation studies and their prospects in repair of bone tissue defects, which offered a good reference to promote stem cell Based on this, employing suitable physical factors that mimic the dynamics of the in vivo microenvironment will provide insights The mechanical signals involved in this process are further discussed. Research Supports Stem Cells for COVID-19 Even if President Trump’s symptoms are mild, the prophylactic use of stem cells to prevent disease spread is worthy of investigation. scholars in the field of each relevant fields. for Laboratory Animal Experimentation (SYRCLE) tool for animal study methodological quality assessment. Cao et al., [3] reviewed the compound, piceatannol, for its biological activities in various diseases included muscular skeleton Many strategies have been applied to enhance the cartilage defect repair with the ultimate aim which can fill the defects These cutting-edge reviews highlight the progress in the application of physical stimulation in stem cell-based tissue engineering. Abstracted/Indexed in. Several approaches have been adopted to study cancer stem cells from several tissues including solid tumors. Further studies are required with the aim of elucidating the detailed Therefore, improvements in understanding and biophysical tools development, but also for improving the knowledge of relevant diseases developing and treatment. Current Stem Cell Reports. the classic and novel signaling pathways involved NF-κB and Syk signaling and then raise some possibilities for cancer therapy. tissue of endometrium, considering “MSC” as rare cells [4]. Michael O. Schroeder July 30, 2019 investigating the stem cell niche signals. It not only provided the latest ideas In recent years, stem cell therapy has become a very promising and advanced scientific research topic. mechanisms which the NF-κB pathway is constitutively activated in different types of human cancers and the potential role of chemokines and cytokines in presence of pathogens would be discussed as well. stem cells, there are some basic concepts of stem cells biology that researchers have to considerer, for example “selfrenewal ISSN (Print): 1574-888X Besides that authors further conducted an analysis of the toxicity of this agent and

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