Human mesenchymal stem cells modulate B-cell functions. J. 1831, 49–58. In particular, TGFβ secreted from cancer cells plays a key role in the differentiation of MSCs into CAFs (Jotzu et al., 2011; Barcellos-de-Souza et al., 2016; Aoto et al., 2018). Cartil. Medi. Figure 1. They are pluripotent cells that support both mesenchymal and hematopoietic cell lineages. In addition to scaffolds, biomaterials are used to encapsulate cells, protecting them from the host while allowing the diffusion of nutrients and therapeutic agents. This approach bases on the implantation of biodegradable fibrin scaffolds seeded with MSCs into the resection cavity to eradicate residual tumor cells in patients receiving surgical removal, with the ultimate goal of increasing cancer-free survival. doi: 10.1158/1078-0432.CCR-13-1415, Li, W., Zhou, Y., Yang, J., Zhang, X., Zhang, H., Zhang, T., et al. Ther. Furthermore, MSCs are able to promote the generation of regulatory T cells (Maccario et al., 2005), which exert immunosuppressive effects. Please try again. A recent report demonstrated that breast cancer cell engulfment of MSCs leads to changes in the transcriptome profile of tumor cells, mainly associated with oncogenic pathways (Chen et al., 2019). Cell. (2012). In this study, the authors described that MSC-treated pigs exhibit increased angiogenesis, reduced apoptosis and decreased fibrosis in the ischemic heart. 34:52. doi: 10.1186/s13046-015-0172-3, Li, X., Liu, L. L., Yao, J. L., Wang, K., and Ai, H. (2019). 6:194. doi: 10.1186/s13287-015-0185-z. These paracrine agents can be directly secreted into the tumor milieus or secreted via EVs. A mechanistic study of the inhibitory effect of MSCs on breast cancer cells demonstrated that the protein Dickkopf-1 (Dkk-1) released from MSCs blocks tumor growth via depression of Wnt signaling (Qiao et al., 2008a). Stem Cell Rev. Pharmacother. (2013). (2018). Mol. 9:104. doi: 10.1186/s13287-018-0850-0, Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F., Krause, D., et al. Bioeng. Sci. For example, an in vitro study showed that MSCs isolated from gastric tumors mediate cancer progression through secretion of Interleukin 8 (IL8) (Li et al., 2015), a pro-inflammatory chemokine that favors the recruitment of leukocytes. We are definitely moving closer to generate a safe and effective medicinal product for cancer that will improve survival and quality of life of patients suffering this devastating disease. 157, 586–598. Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Res. 17, 476–483. 89, 267–270. Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. (2015). Proc. J. Haematol. Acad. PLoS One 13:e0195891. In addition, they show antiapoptotic effects after transplantation and can orchestrate the microenvironment of tumors by modulating the tumor stromal architecture, immune system, and angiogenesis. Biotechnol. (2018). Pluripotency of mesenchymal stem cells derived from adult marrow. Cell-cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models. 18, 553–562. doi: 10.1016/j.imlet.2007.10.002, Escacena, N., Quesada-Hernandez, E., Capilla-Gonzalez, V., Soria, B., and Hmadcha, A. Cancer Res. Although compelling evidences show a pro-tumorigenic role of MSCs, these cells also have potent tumor suppressive effects that have been exploited as cancer therapeutics. Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis. Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine. 14, 329–336. Althoug… Lee, H. K., Finniss, S., Cazacu, S., Bucris, E., Ziv-Av, A., Xiang, C., et al. For instance, the pathological conditions of each patient may induce cellular and molecular changes in MSCs that interfere with their therapeutic effects (Capilla-Gonzalez et al., 2018; Perez et al., 2018; Rivera et al., 2019). Cancer is still a challenging disease to treat… For instance, metastatic human breast carcinoma cells were found to induce the secretion of the chemokine (C-C motif) ligand 5 (CCL5) from MSCs, which enhanced tumor invasion (Karnoub et al., 2007). The role of Gliadel wafers in the treatment of high-grade gliomas. Mesenchymal Stem Cells in Human Health and Diseases, https://doi.org/10.1016/B978-0-12-819713-4.00010-4. Different variants of the oncolytic herpes simplex virus has also been used to arm MSCs that effectively track metastatic tumor lesions and prolong survival of mice with brain metastatic melanomas (Du et al., 2017). doi: 10.1007/s40139-014-0045-z, Connick, P., Kolappan, M., Crawley, C., Webber, D. J., Patani, R., Michell, A. W., et al. (2013). Then you can start reading Kindle books on your smartphone, tablet, or computer - no Kindle device required. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. doi: 10.1016/j.stemcr.2015.01.001, Bregy, A., Shah, A. H., Diaz, M. V., Pierce, H. E., Ames, P. L., Diaz, D., et al. doi: 10.1182/blood.v99.7.2532, Diomede, F., Gugliandolo, A., Cardelli, P., Merciaro, I., Ettorre, V., Traini, T., et al. The therapeutic benefits of MSCs have prompt their use in cell-based strategies to treat different diseases, including cancer. (2015). We use cookies to help provide and enhance our service and tailor content and ads. Pro- and anti-tumor effects of MSCs. 53, 13–28. Notwithstanding, the versatile differentiation potential of MSCs allows the replacement of damaged or dead cells from different tissues. 13, 5231–5248. doi: 10.1634/stemcells.2005-0319, Jiang, X., Fitch, S., Wang, C., Wilson, C., Li, J., Grant, G. A., et al. (2009). (2007). Expert Rev. Med. The application of mRNA-based gene transfer in mesenchymal stem cell-mediated cytotoxicity of glioma cells. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Mesenchymal stem cells and cancer therapy. 15, 6265–6274. doi: 10.1016/1074-7613(95)90057-8, Wobus, M., List, C., Dittrich, T., Dhawan, A., Duryagina, R., Arabanian, L. S., et al. doi: 10.4049/jimmunol.1402097, Lu, L., Chen, G., Yang, J., Ma, Z., Yang, Y., Hu, Y., et al. 119, 2204–2213. Gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8. Rev. Cancer Ther. Curr. doi: 10.3390/cancers11040491. doi: 10.1007/s10517-015-3017-3, Sakai, S., Kawabata, K., Tanaka, S., Harimoto, N., Hashimoto, I., Mu, C., et al. Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors. Drug-encapsulated nanoparticles offer multiple therapeutic benefits by providing preferential accumulation at the target site, preventing burst release and reducing side effects.

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