phentermine moa

It is also reasonable to consider that individuals with depression may benefit from phentermine’s strong peripheral sympathomimetic effect. The use of drinks that contain alcohol can increase your risk of side effects from phentermine. Arguably the biggest drawback associated with phentermine usage for depression is that it may exacerbate the severity of depressive symptoms in certain users and suicidal ideation. Assuming someone with low cortisol secretion administers phentermine for depression, it is possible that increasing his/her cortisol levels within a healthier range may improve mood. I have used for years and it keeps me level. A study by An, Sohn, and Chung (2013) discussed the association between phentermine and affective (mood) disorders. So with that said, I filled my prescription and within that very first day I felt the difference. Phentermine may increase your thyroid activity. Br J Pharmacol 1971 Oct; 43(2):471P-472P. It’s only used short-term along with exercise, a low-calorie diet, and other behavior changes to decrease weight. Specifically, those with depression could exhibit low norepinephrine, low dopamine, and possibly even abnormal epinephrine levels and/or signaling. Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison. Phentermine also brings down my blood pressure whereas ritalin increased it! Ongoing caloric restriction is known to alter the brain by increasing concentrations of antioxidants, neurotrophic factors (e.g. It can also cause other side effects. Possibly related to depression or a changing body and hormones, I’ve gained around 20 pounds in the last year and a half (started at 168lbs, 5’5″). You should not need a new prescription for this medication to be refilled. Version: 3.01. An overdose of phentermine and topiramate can be fatal. That said, the third case study was interesting in that the individual who experienced mania had a family history of mood disorder, possibly making him more prone to drug-induced mania. Don’t worry about airport X-ray machines. Left Brain vs. If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. Phentermine is understood to function as an effective appetite suppressant, making it useful for weight reduction among those with obesity. Wellbutrin worked for me 20 years ago to quit smoking so would be a good chance it might work as well. As of now, most users are taking phentermine at the same dosage as is needed for the treatment of obesity. Increased blood pressure responses to dopamine and norepinephrine produced by monoamine oxidase inhibitors in man. I have tried all sorts of similar drugs before and none of them provide the relief that Adipex delivers, yet those other drugs are labeled for my ailments and Adipex is not. Examples of these drugs include: Disclaimer: Our goal is to provide you with the most relevant and current information. One reason those with obesity may struggle with depression is a result of poor self-image, as well as inability to find a suitable mate. The drug classification of phentermine is a sympathomimetic amine, meaning it stimulates the sympathetic nervous system. But if that doesn’t work, here are six other hacks to try. For seniors: The kidneys of older adults may not work as well as they used to. We'll break down 25 science-backed habits to help you get you mood on track. Qsymia drug interactions (in more detail). A subset of individuals with depression exhibit hypofrontality or deficient function of the frontal lobes and prefrontal cortex. theta waves) and insufficient amounts of fast-wave activity (e.g. Frustrated that Adipex prescription is limited to two 30-day rounds every six months, because once I was on it, it removed a huge weight of anxiety I never personally acknowledged or realized was even there. A person with depression may find that increased energy leads to more exercise, weight loss improves self-esteem, and appetite suppression leads to caloric restriction [and modulation of neurotrophic factors] – each of which may have a positive effect upon mood. Parke-Davis May, 2007. Included below is a list of speculated characteristics of an individual that may benefit from using phentermine for depression. Note: The author of this site is not engaged in rendering professional advice or services to the individual reader. Upon modulation of peripheral hormones, signal transmission from the peripheral nervous system to the central nervous system is altered – resulting in neurobiological changes. Your doctor may change your dose or tell you to stop taking this medicine if you have not lost a certain amount of weight during the first 12 weeks. Healthline Media does not provide medical advice, diagnosis, or treatment. I again took myself off all meds and decided to manage my depression on my own. Hypofrontality results in impaired executive abilities such as: abstract thinking, attention, complex analysis, emotional regulation, and organization of thoughts. [2] The weight loss is modest. When these two medicines are taken together, your body may not process sympathomimetics properly. 25.Eldepryl (selegiline) US prescribing information. This could reduce symptoms such as brain fog and cognitive dysfunction, making it easier for someone with depression to think clearly. Biochemical aspects of release of norepinephrine and other amines from sympathetic nerve endings. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it. This drug is used along with exercise, a low-calorie diet, and other behavior changes to lose weight. Valvular heart disease. When administered as a standalone agent without the presence of another stimulant, phentermine is considered reasonably safe. These risk factors include high blood pressure, high cholesterol, and diabetes. Administration of phentermine to an individual with one particular “neurobiological footprint” of depression may respond extremely well to its administration. You shouldn’t take phentermine if you’re agitated. There are other drugs available to treat your condition. There are numerous ways by which phentermine may prove helpful for individuals with depression. Some areas of the brain that may be affected by phentermine administration include the: prefrontal cortex, HPA axis, and nucleus accumbens. For people with history of heart disease: You shouldn’t take this drug if you have a history of heart problems. As someone living with severe treatment resistant depression who is in a state of sucidality – few words can express how thankful I am ‘feel myself’ to be present in my body and my mind clear. A person’s appearance and physical health may also improve as a result of weight loss from physical activity – which could also decrease depression. It is also reasonable to hypothesize that phentermine may alter cortisol levels to improve mood. You can take phentermine with or without food. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself. Comments: Am J Psychiatry 1964 Sep;121:245-8. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. There are many individuals that would not benefit from using phentermine as an antidepressant. Taking it again could be fatal (cause death). To help others better understand your situation, provide details including: dosage of phentermine you used, how long you took it, and whether you used any other substances (drugs, supplements, etc.) Phentermine can cause a severe allergic reaction. The second study referenced by researchers was a randomized controlled trial published in 2012 evaluating the safety and efficacy of the drug Qsymia (phentermine plus topiramate). Orally disintegrating tablets (ODT) containing 15 mg, 30 mg, or 37.5 mg phentermine hydrochloride (equivalent to 12 mg, 24 mg, or 30 mg phentermine base, respectively). If they’re more severe or don’t go away, talk to your doctor or pharmacist. Knowing my weight is not spiraling out of control while taking phentermine is also a huge relief – and provides a sense of inner peace. Tell your doctor if you have a history of drug or alcohol misuse. Notify me of followup comments via e-mail. Dysfunction within this particular region may be dictate the severity of depressive symptoms such as motivation, cognitive impairment, and lethargy. Misuse can cause addiction, overdose, or death. [3] Effects on heart related health problems or death is unclear. Breaking the vicious circle by forcing oneself to exercise frequently may be what’s necessary to attenuate depression. Learn effective ways to relieve stress and anxiety with these 16 simple tips.

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