��iZ�'lØ)��P�=� ���#�� a���N$r�4]v3���o�!Ck��¼n����pjn%B���~���)�����.2�k�g�#:�������[��u��0 %%EOF 669 0 obj <>stream 0 Hematopoietic Cell/Bone Marrow Transplant – patient/donor Initial and confirmatory HLA typing 2 x 10ml CPDA (If cell count low – 4 x 10ml CPDA) 1 x 10ml clotted <>/XObject<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 419.52 595.32] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Your immune system uses these markers to recognize which cells belong in your body and which do not. endobj 3 0 obj %PDF-1.5 %���� Human leukocyte antigen (HLA) typing is a way to tell how closely the tissues of one person match the tissues of another person. 2 0 obj ��#F�ۣ��Ala`�`͡�ߋmB9���G#2������OΝ�&�6 You have tissue typing tests if your doctor thinks that you might have a stem cell or bone marrow transplant from someone else (donor transplant). a��}� �d�4Jr�����܁+����XM��[XL��X���-���@l.�sIL�x����K_�_�wtL�b�-��b�i��6�R�$����\.��y �nT��% >����k�H4C�tķT���I�3����������7��W�,��,��L` �˧0��zO !�5� 57 0 obj <> endobj HLA are proteins -- or markers -- found on most cells in your body. a���9�`��kQ%���A��،*l�i�bjN'����Z ބ_.��ռ��JV&Hb���(eD������f3]-`��7�'��E"*k�B��k�Ir��3�m�\m�*S� $0�*G�Wh�'ӵ�t�CP6q2���u �M)��Y.��X qd�E{qD�|D�X�Yl���2'�.s�TH,��˜��R'\%��C��:�:����ڬ��J���-%.a���J�,��� ��U�Rڭ�D�$�5%O�$V��8:m�!k�X��@u�4\:i�io��mU�u@���Z��D�'�8��z��[�%ebO�J�t�h[mL���V�xj�*l橹t��}: ���q�y�hH6qZ� �X��m�p��^�4/�t#��W��Bz�-e3'�gO���� PA$8z���L���^PH[�[J�� e���~|7�p���zI��r.���MerV:��H_�GݡD�cH1��lDA��b`tK KF�:طͻ��d�bT��:_ޭ0�&[N����}��7��}��@�d#TF�ӯI)���N�ns����) ���IC�7���z��z�`�P�aS��\�`�"[��m�n�֓ӳ��?��|����>?ܮmԪ��P�^��� ����o�Ò Y7 R� I���I��59А�V`�Ɂ�́f2��v�F7�7���u64�V�2�Z��0}ѯ=0�rO�Š��:��g���p9��f��G�=�g�|��a2[ݦ����"}������W��[���ŝE�E>��Θ��17ш��U1�&P�ce��=6,*�cS��J%�m!�S�c���j9� !��f������l����_.�^օy�����˳��Vȣg7P�!�;`/Jgl�E ̢h�;�����{U�s� �`n��Q�ʩ�/͆�/(����R�RA�va��P|�� �/��.Pw���.P�)k��Cr���2�Ti9�A�"��Q�0��`�:d�!\�a��Y��g��+n��{���XAقE�v�w0�Qb�QC꽒���`x2�{�r��*��>^��e�qыS�y��Q�)o���k!�O������ԯ:�Io��Hz���@M4�V�,���\��P0y`������+���>��F��Uc{nf���ժ�VYu;�sD�fn�� �����uW������q(��iCJ1�1����X��d$��Xb�ȱ�Q �&�ǒ��r����+�W�Һ�W5�W��W����V�|���j} U5=T� {���_%γ���[�����-�K�`yw[��:�9���|Z$�wuX��\��\'�F���ھ��6`��qC�+���}� ���r�}���� n�ʄ�bGY䜎_��mFF���QaT\\��>u�ۅ�= B|B� x���WSZQ�cb��wlĂ+��`�� stream %PDF-1.6 %���� endstream endobj 562 0 obj <>/Metadata 13 0 R/Pages 559 0 R/StructTreeRoot 26 0 R/Type/Catalog>> endobj 563 0 obj <>/MediaBox[0 0 595.32 841.92]/Parent 559 0 R/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 564 0 obj <>stream h�bbd``b`��/�C2�`�S/@���$� ��".��v��3 �D � $8w �yL끄��Xx�����$�xFb��L�~ b�E 4�PbH%��T�0��@��K��Ԃ`��A9e7�# �"���*%Q�+��U�gzCr��UC{�@�Ѡ� &"���uE �B�.D�0��Q�=�%q̀`R. :�cC�>�+,����cf�OM��Cdwߖ�O� %���� How donors and patients are matched 1 0 obj x�]��j� ��>���Ec�!�-����} ��ThT�9��;��:��c���f������S0f��� װ%�0��. In bone marrow transplants, DNA testing is done to determine whether the leukocytes and their precursors repopulating a recipient’s bone marrow are their own or those of the donor. People can also volunteer to have their HLA type included in a bone marro… Your white blood cells have proteins called HLA markers on their surface. endstream endobj 565 0 obj <>stream endobj [t�5� 1��B�rT*�84�_Gs��D�x�a�%-�)�ݝPb���B��. It is important in bone marrow and stem cell transplants to know how closely the transplant recipient matches their donor. endstream endobj startxref By far, the most common reason for HLA typing is to help determine which people can provide the safest tissue transplants (solid organ or hematopoietic stem cell transplantation).1 Potential tissue recipients must have the typing, as must anyone who might potentially want to donate tissue. T[D�s�v 9�u�0쌔fl�ſ�D���[�^�ID��my�V�`V蹥b���M��f}�U�g���������y�nk�q�a��D7�H��ң]"�j9֠��t �*���!h��.ߕ,Tz��;�4��W���ieK;k�u,4�F醼��9q�?��w� Human leukocyte antigen (HLA) typing is used to match patients and donors for bone marrow or cord blood transplants. 561 0 obj <> endobj Tissue Typing for Potential Sibling Stem Cell or Bone Marrow Donors Bone Marrow Transplant Unit Information for potential donors i 2 What is a tissue type? This is called ‘rejection’. <> Why do I need this blood test? When cells or tissues are transplanted from one person to another, the donor HLA type can be recognised by the patient’s body as ‘different’. endobj <> 5 0 obj 0 endstream endobj startxref <> \�,��t����'� ь(f@V�@N n�Q�kE��յ&�a��h��jG4���� h�ځ8h��nt�0�Q�E�e�n4����Ӝ���ܐO�����Z?$z:!�^? %PDF-1.5 x��XMo7����n �~3r��.j�m����Ȳ+@�\Ii���ve[��J� g����f8KN��ݻӫ��������9h���[~����D+�5�l,��Tʀ&*蓊V�����p ��zQQ�bP�z�ƪ`�~8��igZG?��w�#�� ��AtF�����J��s��Ŋ�zP����ˀ�>��� W���nveL6ڷ��� ��5��T�օ=S��U��+�G u��! endstream endobj 58 0 obj <>>>/EncryptMetadata false/Filter/Standard/Length 128/O(��~ J�e�y� c���x�Fc�y�K���roz\n! 4 0 obj This might include relatives of someone needing a transplant. 87 0 obj <>stream ��|�f��K����2X�3̇��>�4Z�-̆fB�3A�.���Mg������ �4�iM`j"05�h��Z�_3� #��a���U��A�� 1���� )�*�wP���Ƚ�ro_�G��Qvy2O��#���;<=Rww;��斵�e-��wG�[��J\�W[�����Z�j��A����)�!�� U�zP�W8�"G��Q[�)#�KU%D�7G��^QL�����^V@���Kķ�ڄ9�b�m+�" Tissue typing is a set of blood tests that show how closely a possible bone marrow donor’s tissue matches your own. endstream h�b```e``6g`c`��ab@ !f�(��ۮv���v`�h`�h P�V��b;�� AF��P��z {��X٘v4�1|8�#���&�i�w�� ��F|@��40:0* �DD8@�30( 1X���Ձ1�1�!��,���� � B d9 4C��c�_�X���nePȂ��3�D9 iF b0 YR%� ?���W�y�'yz|ܑ�Nһ�� 1�ܥ˜x����M6���&�_�l~�+=K�#��X$� ��^������Wt���9�c���o�CJ'�,Y�����0zS�e�^��"��,狔0�5Mf�rN��Wɯ���4O~�[�[� th�=�5���Shv|!�X���S�dx�1�>2����w��Xm?Er8�`W>��� g�$V2�N���WV��WCp�ݢG�ǧX G�眯g stream endobj <>/PageLabels 445 0 R>> 0 �,a 624 0 obj <>/Filter/FlateDecode/ID[<36A728FFFDB77C4B9DAA5F9BFFDA1903>]/Index[561 109]/Info 560 0 R/Length 192/Prev 285810/Root 562 0 R/Size 670/Type/XRef/W[1 3 1]>>stream **�]QQQ�$?Az�������+f���a���������9����仅�+���x�/�\peD̦�9�$r�q9G6�'���18�}�h{��`�� ����ao���;`�a��o����� A short overview from Gift of Life Marrow Registry about tissue typing using human leukocyte antigens (HLAs) and the role this immune system function plays in … k�N ?�+����/���Qi�?���w$�D߬�`��'���c\��>A��5�Ʒ~.藯�\y:~���ƔxG$���?����Z�����%7Pr_���� �W^����^������g�X}�8`�W��]sa��7��kzǤF�T�Ͷ�>N6:�x$�d���}�_��ٴ��o�sߖv�^ڋ~G���3K���~���%}��f���G����Fu����5�P��m��Z����5�R+�I�ņ�Ռ5����˼�w�i��~��93�]"�����\�O�s W�YS�T��i���x�� ��+��e!�\�� X�w�]�>����G�F;MW/������(�XT\��9o������[�xa�=� ��.�a֮�z������M���mm�u?��b����ÒvC���fF9��\,�k���l���`����H͐�W��Ն��W&�{l��:��|'�*ŭEst�����2��@"���:����rh���En �LR��\00���5˙g��U�#:���+,6;t�7 ���z& ���� Hematopoietic Cell/Bone Marrow Transplant – patient/donor Initial and confirmatory HLA typing 2 x 10ml CPDA (If cell count low - 4 x 10ml CPDA) 1 x 10ml clotted 1 … %%EOF h���� 77 0 obj <>/Encrypt 58 0 R/Filter/FlateDecode/ID[<6B529C36A47C478FBEF52E9C04B0C7F8><8E7D588A030DE145819D49469548354A>]/Index[57 31]/Info 56 0 R/Length 96/Prev 102902/Root 59 0 R/Size 88/Type/XRef/W[1 2 1]>>stream ��|d�tG�t�w�)O�'� $ON��/��@�aG �@J If this happens then the patient’s immune system may respond by trying to destroy the transplanted cells.
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