Yes Latent tuberculosis infection is a growing concern. Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden, The present study focused on analysing the introduction of a borderline range around the dichotomous cut-off for QFT to improve clinical interpretation and validity of the test. Results of routine QFT samples from Sweden (2009–2014) were collected. Sweden is a low-TB incidence country and had an overall incidence of 6.9–7.1/100 000 during the study period (2009–2014). There was no clear separation in the distribution of results below and above the cut-off of 0.35 IU/ml, demonstrating an overlap between negative and positive results, (Fig 1). IGRAs detect memory T-cell responses following previous exposure to M. tuberculosis antigens and therefore a positive test is not necessarily associated to the presence of viable bacteria [1]. In the US, up to 13 million people have latent tuberculosis infection (LTBI). Yes A recent systematic review showed a variability of ±0.26–0.7 IU/ml for QFT results in the 0.25–0.8 IU/ml range independent of pre-test probability (indication for testing) [15]. The project was approved by the Regional Ethical committee in Stockholm (DNR 2014/217-31/4 and 2015/1772-32). Funding: This study was funded (all granted to Thomas Schön) by the Swedish Research council, grant 201602043 (www.vr.se) and the Swedish Heart and Lung Foundation (Oscar II Jubilee foundation) grants 20150236 and 20150237 (www3.hjart-lungfonden.se). The TB-PCR is one of the tests that helps diagnose and confirm an infection of Tuberculosis. For more information about PLOS Subject Areas, click Data curation, The TB-PCR test is ordered to diagnose and detects M.Tuberculosis from other mycobacteria. A band will be tightly placed in your arm so that blood fills up in your vein and they are easily visible. NIL 0.07 IU/mL KS MITOGEN-NIL >10.00 IU/mL KS TB-NIL 0.00 IU/mL KS The Nil tube value is used to determine if the patient has a preexisting immune response which could cause a Not surprisingly, recent data suggest that the new QFT version will also show a considerable variability around the cut-off at least in the range of the QFT Gold In tube [9, 25]. This consent shall supersede any preferences set through Do Not Disturb (DND Register)/ National Customer Preference Register (NCPR). There are several technical factors which could influence the QFT-results as outlined by others and test variability leads to clinical interpretation problems when using a dichotomous cut-off [9, 12, 15]. https://doi.org/10.1371/journal.pone.0187313.s001, https://doi.org/10.1371/journal.pone.0187313.s002, https://doi.org/10.1371/journal.pone.0187313.s003, https://doi.org/10.1371/journal.pone.0187313.s004. Parametric data are presented as medians and inter-quartile ranges (IQR). The person taking the test will clean the area with an antiseptic to prevent infection.
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