This research investigated traditional herbal remedies from the Lao PDR (Laos) to treat symptoms of tuberculosis. Mullein boasts an illustrious history as a favored herbal remedy and, consequently, has found use in various disorders. (2004). NIH Isoniazide and rifampin were used as control treatments.  |  Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent. Evid Based Complement Alternat Med. Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases. Medicinal plants used to treat TB in Ghana International Journal of Mycobacteriology. Volume 4, Issue 2, June 2015, Pages 116–123. The essential oils from A. alata and S. glutinosa plants, and the components identified therein, are candidates as potential phytotherapeutic agents for human tuberculosis control. Epub 2020 Jul 10. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Mullein also is known as American mullein, European or orange mullein, candleflower, candlewick, higtaper and lungwort. 2012 Nov;2(11):2669-81. doi: 10.1002/ece3.360. Address: Boston University Archaeology 2004 Jun;18(6):435-48. doi: 10.1002/ptr.1465. Ecol Evol. In Appalachia, the plant has been used to treat colds and the boiled root administered for croup. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Aims: The current study was designed to document medicinal plant species that are traditionally used to treat tuberculosis (TB) by Ghanaian communities. Centuries-old medical palm leaf manuscripts were analyzed to help determine which plants have been in use over a long period of time, and follow-up field interviews were conducted with contemporary healers about plants that are currently used. Minimal inhibitory concentrations were determined by a colorimetric macrodilution method, following the protocol described by Abate et al. The active ingredient in Ghanaian quinine is an alkaloid called cryptolepine, which people have traditionally used against malaria, hepatitis, septicemia, and tuberculosis. There is no recent clinical evidence to support specific dosage of mullein. University of Southern California. Saudi J Biol Sci. Phytother Res. Epub 2017 Jul 3. Its traditional uses generally have focused on the management of respiratory disorders where it was used to treat asthma, coughs, tuberculosis, and related respiratory problems. Essential oil extraction and analysis were performed as described Stashenko et al. Leaves were applied topically to soften and protect the skin. Centuries-old medical palm leaf manuscripts were analyzed to help determine which plants have been in use over a long period of time, and follow-up field interviews were conducted with contemporary healers about plants that are currently used.  |  There is little evidence to indicate that the plant can offer more than mild astringent and topical soothing effects. Fadipe VO, Mongalo NI, Opoku AR, Dikhoba PM, Makhafola TJ. J Insect Sci. ScienceDaily. 2012;12:56. doi: 10.1673/031.012.5601. This is an alphabetical list of plants used in herbalism.. Development of effective strategies for treatment of human tuberculosis has posed a challenge, considering the increase in infections associated with the human immunodeficiency virus and immunocompromised patients. Results: Methods to study the phytochemistry and bioactivity of essential oils. The plant part traditionally used was then extracted into ethanol and/or water and submitted to various biological assays in order to determine the amount of inhibition of virulent Mycobacterium tuberculosis H37Rv (Mtb), as opposed to other microbes and mammalian Vero cells. Data sources include IBM Watson Micromedex (updated 1 Oct 2020), Cerner Multum™ (updated 1 Oct 2020), Wolters Kluwer™ (updated 30 Sep 2020) and others. Time-kill curve assays demonstrated the bacteriostatic activity of these essential oils. Although the drugs used in the initial treatment regimen for TB cross the placenta, they do not appear to have harmful effects on the fetus. Methods: The medicinal plants used against TB or its signs and symptoms were selected using library and online published data searches. Select one or more newsletters to continue. USA.gov. Get the latest research from NIH: https://www.nih.gov/coronavirus. Clinical research is lacking. The in vitro antitubercular activity of essential oils from 11 medicinal plants grown in Colombia were assessed for efficacy as new medications (phytomedicines) for treatment of M. tuberculosis H37Rv. Of the collected species, 15.6% exhibited greater than 90% inhibition of Mtb growth (12 of 77 plants). 2003 Sep;17(8):903-8. doi: 10.1002/ptr.1377. BMC Complement Altern Med. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. (2020, June 8). Isolation of anti-mycobacterial compounds from Curtisia dentata (Burm.f.) A review of medicinal plant of Middle East and North Africa (MENA) region as source in tuberculosis drug discovery. (1998). Verbascum thapsus, V. phlomoides, V. thapsiforme. The common mullein, usually found throughout the US, is a woolly-leafed biennial plant. Epub 2012 Sep 27. NLM Research reveals no reports of serious toxicities with mullein. 2017;2017:7185649. doi: 10.1155/2017/7185649. Conclusions: Information regarding safety and efficacy in pregnancy and lactation is lacking. Antibiotic used to treat tuberculosis could be surprise treatment for deadly superbug. 2020 Sep;27(9):2457-2478. doi: 10.1016/j.sjbs.2020.07.007. During its first year of growth, the large leaves form a low-lying basal rosette. Preparations of the plant have been ingested, applied topically, and smoked. However, in its various forms, the plant has been used to treat hemorrhoids, burns, bruises, and gout. Plants from Puerto Rico with anti-Mycobacterium tuberculosis properties. Joseph Mwanzia Nguta a, b, , Regina Appiah-Opong a, Alexander K. Nyarko a, Dorothy Yeboah-Manu c, Phyllis G.A. Dehyab AS, Bakar MFA, AlOmar MK, Sabran SF. However, classical use of the herb was 3 to 4 g daily. In the spring of the second year, the plant develops a tall stem that can grow to more than 1.22 m in height. A group of 22 plants was screened for activity against Mycobacterium tuberculosis H37Rv and Mycobacterium avium at concentrations from 50 to 200 µg/mL. Please enable it to take advantage of the complete set of features! Sign up and spread the word! The yellow flowers once were used as a source of yellow hair dye. Available for Android and iOS devices. SOE now has a student listserv. Essential oils from Achyrocline alata and Swinglea glutinosa were the most active with minimal inhibitory concentrations of 62.5 +/- 0.1 and 100 +/- 36 microg ml(-1), respectively. 2017 Jun 12;17(1):306. doi: 10.1186/s12906-017-1818-9. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Objective: Mullein has expectorant and cough suppressant properties that make it useful for symptomatic treatment of sore throat and cough. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Development of effective strategies for treatment of human tuberculosis has posed a challenge, considering the increase in infections associated with the human immunodeficiency virus and immunocompromised patients. We comply with the HONcode standard for trustworthy health information -. Frame AD, Ríos-Olivares E, De Jesús L, Ortiz D, Pagán J, Méndez S. Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J. Phytother Res. 2017. An oil derived from the flowers has been used to soothe earaches. It may have mild demulcent properties when ingested. This, along with the stamens, constitutes the active ingredient. Introduction: The aim of this study was to evaluate plants used in Mexican traditional medicine to treat respiratory diseases for activity against MDR‐TB. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Its traditional uses generally have focused on the management of respiratory disorders where it was used to treat asthma, coughs, tuberculosis, and related respiratory problems. Room 345, 675 Commonwealth Ave., Boston, MA 02215, ELKINGTON, Bethany G. - Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago; Field Museum of Natural History, Chicago, IL USA, Kongmany SYDARA - Institute of Traditional Medicine, Vientiane, Lao PDR, Scott G. FRANZBLAU - Institute for Tuberculosis Research, University of Illinois at Chicago, USA, D. Doel SOEJARTO - Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago; Field Museum of Natural History, Chicago, IL USA, Becoming a Researcher: Making the Transition to Graduate School, by Steve Wolverton, Small Things Forgotten: Artifacts of Fishing in the Petén Lakes Region, Guatemala, Secwepemc People and Plants: Research Papers in Shuswap Ethnobotany, Graduate Ethnobiology Research Fellowships, Indigenous People’s Conference Travel Award, Rapid Assistance Fund for Indigenous Communities & Individuals in Need. This site needs JavaScript to work properly. Human tuberculosis is a contagious-infectious disease mainly caused by Mycobacterium tuberculosis. [Development of antituberculous drugs: current status and future prospects]. 1998 Jan;41(1):131. Parts of the plant as well as the berries were used to treat constipation, tuberculosis, swelling, cuts, arthritis, venereal diseases, stomach troubles, fever, broken bones, mosquito bites, sore eyes, acne, boils, gallstones, toothache, headache, and a gynecological problems. Carvacrol, thymol, p-cymene, 1,8-cineole, limonene, and beta-pinene were the major components, most often identified in the 11 plant extracts of essential oils. Essential oils--volatile, aromatic oil extracts from plants--have been used in traditional treatment of many diseases; however careful investigation of these oils has not been undertaken with respect to treatments of tuberculosis. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Genetic structure along an altitudinal gradient in Lippia origanoides, a promising aromatic plant species restricted to semiarid areas in northern South America. Addo d; Open Access. turmeric, echinacea, milk thistle, saw palmetto, creatine. Antiviral activity of mullein has been reported against herpes and influenza. This research investigated traditional herbal remedies from the Lao PDR (Laos) to treat symptoms of tuberculosis. … Evid Based Complement Alternat Med. Material and methods: Methyl eugenol: its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination. Sanusi SB, Abu Bakar MF, Mohamed M, Sabran SF, Mainasara MM. COVID-19 is an emerging, rapidly evolving situation. Tuberculosis treatment consists in an intensive phase and a continuation phase. However, in its various forms, the plant has been used to treat hemorrhoids, burns, bruises, and gout. Although regimens exist for treating tuberculosis, they are far from ideal. C.A.Sm (Curtisiaceae). The top portion of the stem develops yellow flowers that have a faint, honey-like odor. Contraindications have not yet been identified. Clipboard, Search History, and several other advanced features are temporarily unavailable. HHS Bactericidal and bacteriostatic activity was measured using the method developed by the Clinical and Laboratory Standards Institute consigned in the M26-A protocol. The ability to synthesize a wide variety of chemical compounds that are possibly used to perform important biological functions, and to defend against attack from predators such as insects, fungi and herbivorous mammals is called herbal medicine. Indian J Pathol Microbiol. Samples were collected for 77 traditionally-used plants.

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