Why it's done. 2. Of the 700 patients with DLBCL who underwent auto-HCT, 248 (35%) relapsed after auto-HCT. HHS 2018 Feb 15;124(4):816-825. doi: 10.1002/cncr.31114. Summary Eligibility for people ages up to 17 years (full criteria) Location at UCSF … Autologous. Sircar A, Chowdhury SM, Hart A, Bell WC, Singh S, Sehgal L, Epperla N. Int J Mol Sci.  |  Eligibility criteria included adult patients (age ≥18 years) with DLBCL experiencing disease relapse after auto-HCT performed during 2006 to 2015. This site needs JavaScript to work properly. eCollection 2020. h�b```���<� ��ea�X�#0��A|������v~~!x��!���@U�J� �nܾ�v��?b��ƺ��q�o6� ��93�����( q��.�����2\#:::�=::�< �Q��a�V �e``�b@� 1e`�d�f�f��,�l����>�3�l�]��-��T���Θ���) ��8�o�]�1. 0 Epub 2013 May 27. Epub 2016 Aug 29. Autologous stem cell transplantation is currently considered the standard of care for multiple myeloma in young patients with adequate organ function, based on the results of trials conducted in the era prior to the advent of novel agents. Epub 2015 Aug 17. This enables users to easily identify high quality papers relevant to their specific area of interest and to keep up-to-date in their field. Early failure of frontline rituximab-containing chemo-immunotherapy in diffuse large B cell lymphoma does not predict futility of autologous hematopoietic cell transplantation. Epperla N, Vaughn JL, Othus M, Hallack A, Costa LJ. Epperla N, Shah N, Hamadani M, Richardson K, Kapke JT, Patel A, Teegavarapu SP, Carrum G, Hari PN, Pingali SR, Karmali R, Fenske TS. 4. %%EOF The Stem Cell Evidence Alert is a digest of the top articles for current awareness in haematopoietic stem cell transplantation. Stem Cell Evidence is updated regularly. Ma J, Yan Z, Zhang J, Zhou W, Yao Z, Wang H, Chu J, Yao S, Zhao S, Zhang P, Xu Y, Xia Q, Ma J, Wei B, Yang S, Liu K, Guo Y, Liu Y. Biomark Res. Clipboard, Search History, and several other advanced features are temporarily unavailable. This is called an allogeneic transplant. 2020 Aug;9(15):5519-5525. doi: 10.1002/cam4.3237. endstream endobj 527 0 obj <. Allogeneic hematopoietic cell transplantation for diffuse large B cell lymphoma: who, when and how? 2016 Dec;16(12):672-678. doi: 10.1016/j.clml.2016.08.018. Each month, the most important articles in the field are highlighted and the Stem Cell Evidence Alert is sent out to subscribers. A genetic predictive model for precision treatment of diffuse large B-cell lymphoma with early progression.  |  This enables users to refine a search using filters, or browse the database to gain an overview in a subject area. 526 0 obj <> endobj Both the Stem Cell Evidence database and the Stem Cell Evidence Alert are available free of charge. %PDF-1.6 %���� NCI CPTC Antibody Characterization Program. Epub 2020 Jun 18. An autologous stem cell transplant might be an option if your body is producing enough healthy bone marrow cells.  |  h�bbd```b``N��+�d�d) �L`���&�������� �� �}&��H�@�q�k��LڃH��-3@$� Xo+�= $�'�00120��g`$������@� �X 2015 Nov;50(11):1393-404. doi: 10.1038/bmt.2015.184. Recent survival trends in diffuse large B-cell lymphoma--Have we made any progress beyond rituximab? On multivariate analysis, although late relapse (hazard ratio [HR], 0.21; 95% CI, 0.13-0.34; P < .0001) was associated with significantly lower mortality, the risk of mortality increased with age (HR, 1.25 per decade; 95% CI, 1.06-1.48; P = .009). 2014 Jan;49(1):1-7. doi: 10.1038/bmt.2013.72. Post-autologous transplant maintenance therapies in lymphoid malignancies: are we there yet? Articles which meet our eligibility criteria and clinical scope are entered into the database and search filters applied to them. Ford PA, Grant SJ, Mick R, Keck G. Autologous Stem-Cell Transplantation Without Hematopoietic Support for the Treatment of Hematologic Malignancies in Jehovah's Witnesses. Conflict-of-interest disclosure: The authors declare no competing financial interests. Biol Blood Marrow Transplant. Long-term outcomes among 2-year survivors of autologous hematopoietic cell transplantation for Hodgkin and diffuse large b-cell lymphoma. Get the latest research from NIH: https://www.nih.gov/coronavirus. The following types of stem cell transplants may be used with multiple myeloma. Bone Marrow Transplant. We studied outcomes of such patients using data from 4 transplantation centers. J Clin Oncol 2015; 33:1674. Get the latest public health information from CDC: https://www.coronavirus.gov. 2020 Jan 30;21(3):904. doi: 10.3390/ijms21030904. Quality Selection Criteria for Bone Marrow/Stem Cell Transplants 5. Business Selection Criteria 6. Both the Stem Cell Evidence database and the Stem Cell Evidence Alert are available free of charge. Cancer Med. doi: 10.1371/journal.pone.0225035. Our search filters are structured in the following way: Articles must meet strict eligibility criteria to be selected for Stem Cell Evidence. Stem Cell Evidence is an open access, comprehensive collection of high quality research relevant to haematopoietic stem cell transplantation. The Stem Cell Evidence Alert is a digest of the top articles for current awareness in haematopoietic stem cell transplantation. The primary end point was postrelapse overall survival (PR-OS). NIH NLM Klyuchnikov E, Bacher U, Kroll T, Shea TC, Lazarus HM, Bredeson C, Fenske TS. 2014 Nov;20(11):1729-36. doi: 10.1016/j.bbmt.2014.06.036. The database is limited to systematic reviews, randomised controlled trials, overviews of systematic reviews, registry based studies, and observational studies that meet minimum patient number criteria. A stem cell transplant can involve taking healthy stem cells from the blood or bone marrow of one person – ideally a close family member with the same or similar tissue type (see below) – and transferring them to another person. 2020 Aug 26;8:33. doi: 10.1186/s40364-020-00214-3. Vogl DT, Wang T, Pérez WS, et al. Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation. Eligibility criteria included adult patients (age ≥18 years) with DLBCL experiencing disease relapse after auto-HCT performed during 2006 to 2015. Impact and Intricacies of Bone Marrow Microenvironment in B-cell Lymphomas: From Biology to Therapy. Please enable it to take advantage of the complete set of features! A stem cell transplant is a complex procedure that must be done in specialized transplant centres or hospitals. Myers RM, Hill BT, Shaw BE, Kim S, Millard HR, Battiwalla M, Majhail NS, Buchbinder D, Lazarus HM, Savani BN, Flowers MED, D'Souza A, Ehrhardt MJ, Langston A, Yared JA, Hayashi RJ, Daly A, Olsson RF, Inamoto Y, Malone AK, DeFilipp Z, Margossian SP, Warwick AB, Jaglowski S, Beitinjaneh A, Fung H, Kasow KA, Marks DI, Reynolds J, Stockerl-Goldstein K, Wirk B, Wood WA, Hamadani M, Satwani P. Cancer. Quality in blood and tissue establishments and hospital blood banks, 3: Care and selection of whole blood and component donors (including donors of pre-deposit autologous blood), 4: Premises and quality assurance at blood donor sessions, 5: Collection of a blood or component donation, 6: Evaluation and manufacture of blood components, 8: Evaluation of novel blood components, production processes and blood packs: generic protocols, 9: Microbiology tests for donors and donations: general specifications for laboratory test procedures, 10: Investigation of suspected transfusion-transmitted infection, 12: Donation testing (red cell immunohaematology), 13: Patient testing (red cell immunohaematology), 14: Guidelines for the use of DNA/PCR techniques in Blood Establishments, 15: Molecular typing for red cell antigens, 21: Tissue banking: tissue retrieval and processing, 23: Specification for the uniform labelling of blood, blood components and blood donor samples, 24: Specification for the uniform labelling of human tissue products using ISBT 128, 25: Standards for electronic data interchange within the UK Blood Transfusion Services, 26: Specification for blood pack base labels, 27: Specification for labelling consumables used in therapeutic product production, Annex 1: Standards available from the National Institute for Biological Standards and Control, Annex 2: ISBT 128 check character calculation, Annex 5: Blood Components for Contingency Use, Bone Marrow and Peripheral Blood Stem Cell, 4: Safe transfusion – right blood, right patient, right time and right place, 6: Alternatives and adjuncts to blood transfusion, 7: Effective transfusion in surgery and critical care, 8: Effective transfusion in medical patients, 9: EFFECTIVE transfusion in obstetric practice, 10: Effective transfusion in paediatric practice, 12: Management of patients who do not accept transfusion, Aide Memoir Interpretations\Clarifications, Principles of the EI Guidance Issued by the MHRA. © 2019 by The American Society of Hematology. See this image and copyright information in PMC. Stem Cell Evidence’s Clinical Management Group is headed by Dr James Griffin, who works closely with the SRI but is independent of the group. ?�|�gu��s@h>3�l ��w _20�D�CF��e�>�*�E '�WW This is the largest study to date to evaluate outcomes of DLBCL patients relapsing after auto-HCT. Stem Cell Evidence aims to be a key resource worldwide for medical practitioners, clinical researchers and policy makers. Outcomes for diffuse large B-cell lymphoma (DLBCL) patients relapsing after autologous hematopoietic cell transplantation (auto-HCT) have been historically poor.

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