At my institution, post-induction systemic treatment continues without transplant, instead relying on anti-GD2 antibody followed by anti-neuroblastoma vaccine. A phase III randomized clinical trial of tandem myeloablative autologous stem cell transplant using peripheral blood stem cell as consolidation therapy for high risk neuroblastoma: A Children’s Oncology Group study. 2005;doi:10.1002/pbc.20219. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Using Tandem Transplants to Treat Neuroblastoma was originally published by the National Cancer Institute.”. Nearly half of the original cohort ultimately wasn't randomized to double versus single transplant. Treatment of high-risk neuroblastoma in North America largely is driven by the experience of Children’s Oncology Group (COG), the world’s largest pediatric cancer cooperative group. Our syndication services page shows you how. In sequential studies at Memorial Sloan Kettering Cancer Center, transplant did not improve OS, whereas anti-GD2 murine antibody 3F8 plus GM-CSF did. Taken together, tandem transplant should be considered standard for all children with biologically unfavorable high-risk neuroblastoma who respond to COG-like induction chemotherapy. The cancer originates in immature nerve cells, and neuroblastoma tumors often form in and near the abdomen and in the chest or neck region along the spine. Before the COG trial, the standard treatment for high-risk neuroblastoma was a single-transplant approach that involved high-dose chemotherapy to destroy as many cancer cells as possible, followed by an autologous (self-donating) blood stem cell transplant. Pediatric oncologist and researcher Julie Park has devoted her career to try to change that. Only observation is required for some patients, whereas for other patients, maximally intensive multimodality therapy is necessary. Treatment includes intensive chemotherapy, aggressive surgeries, double transplant, post-transplant radiation, and immunotherapy. sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), JAMAevidence: The Rational Clinical Examination, JAMAevidence: Users' Guides to Medical Literature, FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles. In a multicenter randomized trial led by investigators at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Seattle Children's Hospital, the double transplant enabled children to survive longer without new or recurrent disease over three years of follow-up. Katie was given a 35% chance of survival, and, on the advice of doctors, her parents immediately enrolled her in the COG trial. 2015;doi:10.1200/JCO.2014.59.4648. Phys.org internet news portal provides the latest news on science, Tech Xplore covers the latest engineering, electronics and technology advances, Science X Network offers the most comprehensive sci-tech news coverage on the web. Get free access to newly published articles. Collecting stem cells before the transplant. Find out more in our latest new…, American Society of Clinical Oncology press release, Transformation in lung cancer: driving innovation where patients’ needs are greatest, Managing colorectal cancer patients in the COVID-19 era, News round-up: 11th European Breast Cancer Conference, Labyrinth chip has the potential to lead to customized cancer treatments, Anti-PD1 and anti-PD-L1 in the treatment of metastatic melanoma, Lessons from two domestic wars: cancer and poverty, Research finds potential drug targets for rare pediatric cancer, Theory linking power lines, air pollution and childhood leukemia called into question, Tecentriq® (atezolizumab) combo delivers survival benefit to NSCLC patients. All individuals received six cycles of multi-agent induction chemotherapy regimen, including an initial two cycles of high-dose cyclophosphamide/topotecan followed by stem cell collection from the blood to be used for subsequent transplantation. Over the course of a decade, Lisa Diller, MD and her colleagues tested and refined the double-transplant treatment. More than 20 years ago, Matthay and colleagues first reported an improvement in EFS in a randomized phase 3 trial for patients who received myeloablative therapy compared with patients who received continuing chemotherapy. This news piece was also featured on our sister site, Neurology Central. Want to use this content on your website or other digital platform? Your feedback will go directly to Science X editors. In addition, a small cohort of patients with high-risk neuroblastoma with historically favorable clinical outcomes — defined as patients older than 18 months with localized disease, unfavorable histology and nonamplified MYCN status — were nonrandomly assigned to receive single transplant. For many years, less than half of children diagnosed with high-risk neuroblastoma, a cancer that starts in immature nerve cells, would be expected to live 5 or more years after diagnosis. JAMA Oncol. Overall, neuroblastoma accounts for 10 to 12 percent of all child cancer deaths. Children with a median age of 3.1 years who had been newly diagnosed with high-risk neuroblastoma were enrolled onto the trial. In a multicenter randomized trial led by investigators at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Seattle Children’s Hospital, the double transplant enabled children to survive longer without new or recurrent disease over three years of follow-up.

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